Antwerp Centre for Advanced Microscopy

High impact science through systematic and quantitative imaging

Publications

Evaluation of the Kinetics of Antibody Response to COVID-19 Vaccine in Solid Organ Transplant Recipients: The Prospective Multicenter ORCHESTRA Cohort.

Giannella M, Righi E, Pascale R, Rinaldi M, Caroccia N, Gamberini C, Palacios-Baena ZR, Caponcello G, Morelli MC, Tamè M, Busutti M, Comai G, Potena L, Salvaterra E, Feltrin G, Cillo U, Gerosa G, Cananzi M, Piano S, Benetti E, Burra P, Loy M, Furian L, Zaza G, Onorati F, Carraro A, Gastaldon F, Nordio M, Kumar-Singh S, Abedini M, Boffetta P, Rodríguez-Baño J, Lazzarotto T, Viale P, Tacconelli E, On Behalf Of The Orchestra Study Group Workpackage

Microorganisms

2022 May 12

https://doi.org/10.3390/microorganisms10051021

Hyperthermia Enhances Efficacy of Chemotherapeutic Agents in Pancreatic Cancer Cell Lines.

Maurici CE, Colenbier R, Wylleman B, Brancato L, van Zwol E, Van den Bossche J, Timmermans JP, Giovannetti E, Mori da Cunha MGMC, Bogers J

Biomolecules

2022 Apr 29

https://doi.org/10.3390/biom12050651

Identification of Potential Urinary Metabolite Biomarkers of Pseudomonas aeruginosa Ventilator-Associated Pneumonia.

Jongers B, Hotterbeekx A, Bielen K, Vervliet P, Boddaert J, Lammens C, Fransen E, Baggerman G, Covaci A, Goossens H, Malhotra-Kumar S, Jorens PG, Kumar-Singh S

Biomark Insights

2022 May 13

https://doi.org/10.1177/11772719221099131

Fractionated irradiation of MCF7 breast cancer cells rewires a gene regulatory circuit towards a treatment-resistant stemness phenotype.

Inalegwu A, Cuypers B, Claesen J, Janssen A, Coolkens A, Baatout S, Laukens K, De Vos WH, Quintens R

Mol Oncol

2022 Jun 15

https://doi.org/10.1002/1878-0261.13226

Oligodendroglia-derived extracellular vesicles activate autophagy via LC3B/BAG3 to protect against oxidative stress with an enhanced effect for HSPB8 enriched vesicles.

Van den Broek B, Wuyts C, Sisto A, Pintelon I, Timmermans JP, Somers V, Timmerman V, Hellings N, Irobi J

Cell Commun Signal

2022 May 5

https://doi.org/10.1186/s12964-022-00863-x

TNF-α-Secreting Lung Tumor-Infiltrated Monocytes Play a Pivotal Role During Anti-PD-L1 Immunotherapy.

De Ridder K, Locy H, Piccioni E, Zuazo MI, Awad RM, Verhulst S, Van Bulck M, De Vlaeminck Y, Lecocq Q, Reijmen E, De Mey W, De Beck L, Ertveldt T, Pintelon I, Timmermans JP, Escors D, Keyaerts M, Breckpot K, Goyvaerts C

Front Immunol

2022 Apr 14

https://doi.org/10.3389/fimmu.2022.811867

Susceptibility profiles and resistance genomics of Pseudomonas aeruginosa isolates from European ICUs participating in the ASPIRE-ICU trial.

Torrens G, van der Schalk TE, Cortes-Lara S, Timbermont L, Del Barrio-Tofiño E, Xavier BB, Zamorano L, Lammens C, Ali O, Ruzin A, Goossens H, Kumar-Singh S, Kluytmans J, Paling F, MacLean RC, Köhler T, López-Causapé C, Malhotra-Kumar S, Oliver A, ASPIRE-ICU study team

J Antimicrob Chemother

2022 Jun 29

https://doi.org/10.1093/jac/dkac122

Host Immunity Influences the Composition of Murine Gut Microbiota.

Van Averbeke V, Berkell M, Mysara M, Rodriguez-Ruiz JP, Xavier BB, De Winter FHR, Jongers B', Jairam RK, Hotterbeekx A, Goossens H, Cohen ES, Malhotra-Kumar S, Kumar-Singh S

Front Immunol

2022 Mar 15

https://doi.org/10.3389/fimmu.2022.828016

Activation of the Carboxypeptidase U (CPU, TAFIa, CPB2) System in Patients with SARS-CoV-2 Infection Could Contribute to COVID-19 Hypofibrinolytic State and Disease Severity Prognosis.

Claesen K, Sim Y, Bracke A, De Bruyn M, De Hert E, Vliegen G, Hotterbeekx A, Vujkovic A, van Petersen L, De Winter FHR, Brosius I, Theunissen C, van Ierssel S, van Frankenhuijsen M, Vlieghe E, Vercauteren K, Kumar-Singh S, De Meester I, Hendriks D

J Clin Med

2022 Mar 9

https://doi.org/10.3390/jcm11061494

Luminescent Human iPSC-Derived Neurospheroids Enable Modeling of Neurotoxicity After Oxygen-glucose Deprivation.

Van Breedam E, Nijak A, Buyle-Huybrecht T, Di Stefano J, Boeren M, Govaerts J, Quarta A, Swartenbroekx T, Jacobs EZ, Menten B, Gijsbers R, Delputte P, Alaerts M, Hassannia B, Loeys B, Berneman Z, Timmermans JP, Jorens PG, Vanden Berghe T, Fransen E, Wouters A, De Vos WH, Ponsaerts P

Neurotherapeutics

2022 Mar 14

https://doi.org/10.1007/s13311-022-01212-z

Proline-specific peptidase activities (DPP4, PRCP, FAP and PREP) in plasma of hospitalized COVID-19 patients.

Bracke A, De Hert E, De Bruyn M, Claesen K, Vliegen G, Vujkovic A, van Petersen L, De Winter FHR, Hotterbeekx A, Brosius I, Theunissen C, Van Ierssel S, van Frankenhuijsen M, Vlieghe E, Vercauteren K, Van der Veken P, Hendriks D, Kumar-Singh S, De Meester I

Clin Chim Acta

2022 Mar 10

https://doi.org/10.1016/j.cca.2022.03.005

Cellular senescence in neuroblastoma.

Zanotti S, Decaesteker B, Vanhauwaert S, De Wilde B, De Vos WH, Speleman F

Br J Cancer

2022 Feb 23

https://doi.org/10.1038/s41416-022-01755-0

The cellular response to plasma membrane disruption for nanomaterial delivery.

Houthaeve G, De Smedt SC, Braeckmans K, De Vos WH

Nano Converg

2022 Feb 1

https://doi.org/10.1186/s40580-022-00298-7

Vasoconstrictor antagonism improves functional and structural vascular alterations and liver damage in rats with early NAFLD.

van der Graaff D, Chotkoe S, De Winter B, De Man J, Casteleyn C, Timmermans JP, Pintelon I, Vonghia L, Kwanten WJ, Francque S

JHEP Rep

2021 Nov 25

https://doi.org/10.1016/j.jhepr.2021.100412

Genomic and Phenotypic Characterization of Experimentally Selected Resistant Leishmania donovani Reveals a Role for Dynamin-1-Like Protein in the Mechanism of Resistance to a Novel Antileishmanial Compound.

Hefnawy A, Negreira G, Jara M, Cotton JA, Maes I, D'Haenens E, Imamura H, Cuypers B, Monsieurs P, Mouchtoglou C, De Winter H, Pintelon I, Timmermans JP, Berriman M, Sanders M, Martin J, de Muylder G, Dujardin JC, Sterckx YG, Domagalska MA

mBio

2022 Jan 11

https://doi.org/10.1128/mbio.03264-21

Transient nuclear lamin A/C accretion aids in recovery from vapor nanobubble-induced permeabilisation of the plasma membrane.

Houthaeve G, García-Díaz Barriga G, Stremersch S, De Keersmaecker H, Fraire J, Vandesompele J, Mestdagh P, De Smedt S, Braeckmans K, De Vos WH

Cell Mol Life Sci

2022 Jan 4

https://doi.org/10.1007/s00018-021-04099-9

Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled Receptor D Induces Release of the Inflammatory Cytokine IL-6 and Is Dependent on NF-κB Signaling.

Arora R, Van Theemsche KM, Van Remoortel S, Snyders DJ, Labro AJ, Timmermans JP

Int J Mol Sci

2021 Dec 9

https://doi.org/10.3390/ijms222413254

High-LET Carbon and Iron Ions Elicit a Prolonged and Amplified p53 Signaling and Inflammatory Response Compared to low-LET X-Rays in Human Peripheral Blood Mononuclear Cells.

Macaeva E, Tabury K, Michaux A, Janssen A, Averbeck N, Moreels M, De Vos WH, Baatout S, Quintens R

Front Oncol

2021 Nov 23

https://doi.org/10.3389/fonc.2021.768493

ATG4B Inhibitor UAMC-2526 Potentiates the Chemotherapeutic Effect of Gemcitabine in a Panc02 Mouse Model of Pancreatic Ductal Adenocarcinoma.

Takhsha FS, Vangestel C, Tanc M, De Bruycker S, Berg M, Pintelon I, Stroobants S, De Meyer GRY, Van Der Veken P, Martinet W

Front Oncol

2021 Nov 18

https://doi.org/10.3389/fonc.2021.750259

Blood Cytokine Analysis Suggests That SARS-CoV-2 Infection Results in a Sustained Tumour Promoting Environment in Cancer Patients.

De Winter FHR, Hotterbeekx A, Huizing MT, Konnova A, Fransen E, Jongers B, Jairam RK, Van Averbeke V, Moons P, Roelant E, Le Blon D, Vanden Berghe W, Janssens A, Lybaert W, Croes L, Vulsteke C, Malhotra-Kumar S, Goossens H, Berneman Z, Peeters M, van Dam PA, Kumar-Singh S

Cancers (Basel)

2021 Nov 15

https://doi.org/10.3390/cancers13225718

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