Extra- and intracellular vesicles

Transmission electron microscopy (TEM) allows studying the ultrastructure of biological samples at the nanometre scale. ACAM has also implemented methods for investigating small particles with a minimum of artefacts (cryo-TEM) and in 3D (tomography) by means of high-pressure freezing (HPF)/freeze substitution (FS) for the best preservation of the ultrastructure in samples and the latest ultramicrotome for perfect sectioning.